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Sault Ste. Marie is a cross-border region in Canada and the United States. Formerly a single settlement from 1668 to 1817, it was subsequently divided by the establishment of the Canada–US border in the area. Sault Ste. Marie, Ontario has a population of 74,948.

The Sault Ste. Marie Canal is a National Historic Site in Sault Ste. Marie, Ontario, and is part of the national park system, managed by Parks Canada. It includes a lock to bypass the rapids on the St. Marys River.

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